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1991cc金沙棋牌院长黎晖个人简介
2021-03-16 09:52     (浏览次数:)

1991cc金沙棋牌院长黎晖个人简介

黎晖,男,1972年1月出生,湖北省通城县人,研究员,医学博士,博士生导师,现任广州中医药大学1991cc金沙棋牌院长,中医学一级学科方向“中医基础理论传承与创新”学术带头人、中医诊断学二级学科带头人;兼任吴阶平医学基金会模拟医学部副主任委员,中国中医药研究促进会中医人工智能装备分会常务理事,广东省解剖学会常务理事,广东省实验动物学会第一届监事,广东省中西医结合学会实验医学分会副主任委员。2012年获教育部新世纪优秀创新人才,广东省高校第七批“千百十”人才计划省级培养对象。主持国家自然科学基金项目3项,参与3项;主持广东省自然科学基金重点项目、广州市科技计划项目和广东省普通高校重点领域(新一代信息技术专项)各1项;发表论文80多篇,其中SCI论文16篇;获国家发明专利2项。

 

教育经历:

1.2005/9–2010/7, 中山大学, 人体解剖与组织胚胎学, 博士, 导师:姚志彬

2.1999/9–2002/7, 广州中医药大学, 中西医结合基础, 硕士, 导师:李伊为

3.1991/9–1996/7, 广州中医药大学, 中医骨伤科学, 学士, 导师:

科研与学术工作经历:

1.2017/6-至今,广州中医药大学,1991cc金沙棋牌院长,研究员

2.2014/11-2017/6,广州中医药大学,国际交流与合作处(国际学院、港澳台事务办公室)副处长(副院长、副主任),研究员

3.2010/10-2014/11,广州中医药大学,1991cc金沙棋牌副院长,研究员

4.2006/9-2010/10,广州中医药大学,科技处科技开发科科长,副教授、研究员

5.1996/7-2006/9,广州中医药大学,1991cc金沙棋牌解剖教研室,助教、讲师、副教授

 

主持或参加科研项目(课题)及人才计划项目情况:

1国家自然科学基金委员会,面上项目,81873162,牛珀至宝微丸通过HMGB1调控髓源性抑制细胞防治感染性休克,2019-01至2022-12,55万元,在研,主持

2国家自然科学基金委员会,面上项目,81273962,牛珀至宝微丸调控过氧化物酶体增殖物激活受体γ的核内共阻遏机制,2012-012016-12,70万元,已结题,主持

3国家自然科学基金委员会,面上项目,81072908 ,牛珀至宝微丸调控高迁移率族蛋白B1解毒祛邪的分子机制,2010-012013-12,33万元,已结题,主持

4广东省自然科学基金委员会,重点项目,2018B030311014,牛珀至宝微丸调控HMGB1参与核内共阻遏机制防治急性感染性炎症研究,2018-052021-04,50万元,在研,主持

5广州市科技计划项目,201804010113,大黄牡丹皮汤通过miR-155调控高迁移率族蛋白B1防治内毒素休克,2018-042021-03,20万元,在研,主持

6)广东省普通高校重点领域专项(新一代信息技术),2020ZDZX3003,中医人工智能的理论基础与应用,2021-01至2023-12,30万元,在研,主持

7)广东省自然科学基金委员会研究团队项目2017A030312009, 中药小分子调控iPSCs成软骨分化的网络共激活机制2017-052022-05300万元在研,参与

8)国家自然科学基金委员会,地区科学基金项目,81760738,参附注射液扶阳固脱调控高迁移率族蛋白B1与NF-κB结合的分子机制,2018-01至2021-12,34万元,在研,参与

9广东省高层次人才项目,2013-012015-12,25万元,已验收

10教育部新世纪优秀人才计划项目,2012-012015-12,已验收

11第七批广东省高校“千百十”人才计划省级培养对象,2012-012015-12,已验收

12国家自然科学基金委员会,国家基础科学人才培养基金,J1310017,广州中医药大学医学理科基地人才培养条件建设项目,2014-01至2017-12,200万元,已结题,参与

13国家自然科学基金委员会,面上项目,81173377,扶阳固脱法调控高迁移率族蛋白B1启动子的研究,2012-012014-12,已结题,参与

14国家自然科学基金委员会,面上项目,30371837,MSC和中药构建神经组织工程对脊髓全横断损伤的影响,2003-012005-12,已结题,参与

15国家自然科学基金委员会,面上项目,30271677,益肾1号诱导脑缺血大鼠MSC移植后转分化为神经元的研究,2002-012002-12,已结题,参与

 

代表性研究成果和学术奖励情况

一、期刊论文

1. 第一作者论文

(1) Du S.,Li H ,Cui Y.,Yang L,Wu J.,Huang H.,Chen Y.,Huang W.,Zhang R.,Yang J.,Chen D.,Li Y.,Zhang S.,Zhou J.,Wei Z.,Chow N.T.,Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-gamma and inhibiting the TGF-beta 1/Smad pathway,International Immunopharmacology,2012.7.01,13(3):331~340

(2) Li, Hui ,Zou, Juntao,Yao, Zhibin,Yu, Jing,Wang, Huaqiao,Xu, Jie,Tetravalent A beta 1-15 vaccine reduces TCR-positive cell infiltration and up-regulates p75 in Tg2576 brains compared to A beta 42 vaccine,Journal of Neuroimmunology,2010.2.26,219(1-2):8~16

(3) Li, Hui ,Du, Shaohui,Yang, Lina,Chen, Yangyan,Huang, Wei,Zhang,(#) Rong,Cui, Yinghai,Yang, Jun,Chen, Dongfeng,Li, Yiwei,Zhang, Saixia,Zhou, Jianhong,Wei, Zhijun,Yao, Zhibin,Rapid pulmonary fibrosis induced by acute lung injury via a lipopolysaccharide three-hit regimen,Innate Immunity,2009.6.01,15(3):143~154

(4) 黎晖,杜少辉,张赛霞,邓汝东,李春,李伊为,陈东风,周健洪,牛珀至宝微丸对内毒素休克大鼠肺组织高迁移率族蛋白B1表达的影响,中西医结合学报,2009,(05):441~446

(5) 黎晖,周健洪,陈东风,杜少辉,李伊为,邓汝东,张赛霞,龟板对大鼠骨髓间充质干细胞向成骨分化的影响,中药新药与临床药理,2005.6.30,(03):159~161

(6) 黎晖,陈东风,刘金元,周健洪,杜少辉,李伊为,邓汝东,张赛霞,曾和平,壳聚糖-明胶-碱性成纤维细胞生长因子三维大孔支架对骨髓间充质干细胞增殖的影响(英文),中国组织工程研究与临床康复,2008.3.4,(10):1943~1949

(7) 黎晖,刘东辉,以大学科技园为核心大力促进高校产学研合作工作,中国高校科技与产业化,2009.7.15,(07):54~55

(8) 黎晖,浅谈人体解剖学的学习方法,解剖学研究,2014.01.01,(04):311~312

(9) 黎晖,游江,邝枣园,郑洪,浅论中医院校本科生科研素质培养,现代医院,2014.7.15,(07):127~128

 

2. 通讯作者论文(勿与第一作者论文重复)

(1) Lei H,Wen Q,Li H ,Du S,Wu JJ,Chen J,Huang H,Chen D,,Li Y,Zhang S,,Zhou J,Deng R,Yang Q,Paeonol Inhibits Lipopolysaccharide-Induced HMGB1 Translocation from the Nucleus to the Cytoplasm in RAW264.7 Cells,Inflammation,2016.6.01,39(3):1177~1187

(2) 温泉,黎晖,田瑞敏,雷航,细胞之阴阳理论,中医杂志,2014.01.01,13:1081~1085

(3) 温泉,杜少辉,田瑞敏,黎晖,白晔,李菲,雷航,陈东风,李伊为,周健洪,张赛霞,邓汝东,余曜,小鼠高迁移率族蛋白B1启动子的构建与转录活性检测,广州中医药大学学报,2014.01.01,31(5):810~813

(4) 吴晶晶,黄开远,黎晖,杜少辉,邓汝东,张赛霞,周健洪,陈东风,李伊为,β-细辛醚抑制核转录因子Kappa B表达,解剖学研究,2012.01.01,(02):104~106

(5) 陈兰,黎晖,李春,曹佳会,伍艺灵,刘洋,周健洪,陈东风,李伊为,龟版有效成分抗无血清损伤表皮干细胞凋亡的研究,2011,(08):888~893

(6) 李春,陈兰,黎晖,邓汝东,张赛霞,陈东风,李伊为,龟板有效成分抗紫外线损伤所致的胎鼠表皮干细胞的凋亡,解剖学研究,2010.6.25,32(03):165~168

(7) 黄开远,温泉,黎晖,杨开磊,杨伟华,秦红芳,陈静,曾玲,不同盐浓度影响中药外洗方中小檗碱透皮吸收的体外实验研究,时珍国医国药,2013.4.01,24(2):273~275

(8) 刘忆思,刘思艺,黄俊铭,李伊为,黎晖,针对帕金森病致病与相关基因的miRNA研究进展,解剖学研究,2015.4.25,(02):141~145

(9) Wen Q, Mei L, Ye S, Liu X, Xu Q, Miao J, et al. Chrysophanol demonstrates anti-inflammatory properties in LPS-primed RAW 264.7 macrophages through activating PPAR-gamma. International immunopharmacology .2018; 56: 90-97.

(10) Liu X#, Xu Q#, Mei L, Lei H, Wen Q, Miao J, Huang H, Chen D, Du S, Zhang S, Zhou J, Deng R, Li Y, Li C, Li H*. Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock rats. Int Immunopharmacol. 2018 Aug; 61: 169-177.

(11) Xu Q#, Liu X#, Mei L, Wen Q, Chen J, Miao J, Lei H, Huang H, Chen D, Du S, Liu A, Zhang S, Zhou J, Deng R, Li Y, Li C, Li H*. Paeonol Reduces the Nucleocytoplasmic Transportation of HMGB1 by Upregulating HDAC3 in LPS-Induced RAW264.7 Cells. Inflammation. 2018 Aug; 41(4): 1536-1545.

(12) Wen Q, Miao J, Lau N, Zhang C, Ye P, Du S, Mei L, Weng H, Xu Q, Liu X, Chen D, Zhang F, Li C, Li H*. Rhein attenuates lipopolysaccharide-primed inflammation through NF-κB inhibition in RAW 264.7 cells: targeting the PPARγ signal pathway. Can J Physiol Pharmacol. 2019 Dec 17:10.1139/cjpp-2019-0389.

(13) Liyan Mei#, Meihong He#, Chaoying Zhang, Jifei Miao, Quan Wen, Xia Liu, Qin Xu, Sen Ye, Peng Ye, Huina Huang, Junli Lin, Xiaojing Zhou, Kai Zhao, Dongfeng Chen, Jianhong Zhou, Chun Li, Hui Li*. Paeonol Attenuates Inflammation by Targeting HMGB1 Through Upregulating miR-339-5p. Sci Rep. 2019 Dec 18, 9 (1): 19370.

(14) Liang J#, Zhou J#, Xu Y, Huang X, Wang X*, Huang W*, Li H*. Osthole inhibits ovarian carcinoma cells through LC3-mediated autophagy and GSDME-dependent pyroptosis except for apoptosis. Eur J Pharmacol. 2020 May 5; 874: 172990. doi: 10.1016/j.ejphar.2020.

(15) Miao J, Ye S, Lan J, Ye P, Wen Q, Mei L, Liu X, Lin J, Zhou X, Du S, Liu X, Li H*.Nuclear HMGB1 promotes the phagocytic ability of macrophages. Exp Cell Res. 2020 Apr 28: 393(1): 112037.

(16) Jifei Miao, Peng Ye, Jiao Lan, Sen Ye, Jun Zhong, Austin Gresham, Siyan Li, Aijia You, Xianjie Chen, Xiaoyi Liu, Hui Li*. Paeonol promotes the phagocytic ability of macrophages through confining HMGB1 to the nucleus[J]. International Immunopharmacology, 2020, (89): 107068.

(17) 张超颖, 苗纪飞, 许沁,等. 丹皮酚对脂多糖刺激的RAW264.7细胞炎症与自噬的影响[J]. 中国中医基础医学杂志, 2020, 26(6): 768-772,821

 

3. 既非第一作者又非通讯作者论文

(1) Zheng, Qi,Li, Caixia,Li, Hui,Tang, Yong ,Exploring the mechanisms of different treatments for endotoxic shock through literature mining and systems biology,European Journal of Integrative Medicine,2014.2.01,6(1):56~63

(2) Li, Xican,Wei, Gang,Wang, Xiaozhen ,Liu, Dong-Hui,Deng, Ru-Dong,Li, Hui,Zhou, Jian-Hong,Li, Yi-Wei,Zeng, He-Ping,Chen, Dong-Feng,Targeting of the Sonic Hedgehog Pathway by Atractylenolides Promotes Chondrogenic Differentiation of Mesenchymal Stem Cells,Biological & Pharmaceutical Bulletin,2012.8.01,35(8):1328~1335

(3) Chen, Dong-Feng ,Cao, Jia-hui,Liu, Yang,Wu, Yiling,Du, Shao-Hui,Li, Hui,Zhou, Jian-Hong,Li, Yi-Wei,Zeng, He-Ping,Hua, Zi-Chun,BMP-Id pathway targeted by cholesterol myristate suppresses the apoptosis of PC12 cells,Brain Research,2011.1.7,1367:33~42

(4) Chen, Dong-Feng,Li, Xican,Xu, Zhiwei,Liu, Xiaobing,Du, Shao-Hui,Li, Hui,Zhou, Jian-Hong,Zeng, He-Ping,Hua, Zi-Chun,Hexadecanoic Acid from Buzhong Yiqi Decoction Induced Proliferation of Bone Marrow Mesenchymal Stem Cells,Journal of Medicinal Food,2010.8.01,13(4):967~975

(5) Chen, Dong-Feng,Du, Shao-Hui,Zhang, Hai-Ling,Li, Hui,Zhou, Jian-Hong,Li, Yi-Wei,Yi, Xiang-Hua,Hou, Qiu-Ke,Wu, Jing,Zeng, He-Ping,Hua, Zi-Chun,Autocrine BMP4 signaling involves effect of cholesterol myristate on proliferation of mesenchymal stem cells,Steroids,2009.12.01,74(13-14):1066~1072

(6) Zeng, He-Ping,Wang, Ting-Ting,Ouyang, Xin-Hua,Zhou, Ya-Dong,Jing, Hui-Lian,Yuan, Guo-Zan,Chen, Dong-Feng,Du, Shao-Hui,Li, Hui,Zhou, Jian-Hong,8-hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs),Bioorganic & Medicinal Chemistry,2006.8.8,14(16):5446~5450

(7) Wei, Gang,Chen, Dong-Feng ,Lai, Xiao-Ping,Liu, Dong-Hui,Deng, Ru-Dong,Zhou, Jian-Hong,Zhang, Sai-Xia,Li, Yi-Wei,Li, Hui,Zhang, Qiong-Dan,Muscone Exerts Neuroprotection in an Experimental Model of Stroke via Inhibition of the Fas Pathway,Natural Product Communications,2012.8.01,7(8):1069~1074

(8) Chen, Dong-Feng ,Meng, Ling-Jie,Du, Shao-Hui,Zhang, Hai-Ling,Li, Hui,Zhou, Jian-Hong,Li, Yi-Wei,Zeng, He-Ping,Hua, Zi-Chun,(+)-Cholesten-3-one induces differentiation of neural stem cells into dopaminergic neurons through BMP signaling,Neuroscience Research,2010.11.01,68(3):176~184

(9) Chen, Dong-Feng ,Zhang, Hai-Ling,Du, Shao-Hui, ,Zhou, Li, Hui Jian-Hong,Li, Yi-Wei,Zeng, He-Ping,Hu, Zi-Chun,Cholesterol myristate suppresses the apoptosis of mesenchymal stem cells via upregulation of inhibitor of differentiation,Steroids,2010.12.12,75(13-14):1119~1126

(10) Chen, D. F.,Zeng, H. P.,Du, S. H.,Li, H.,Zhou, J. H.,Li, Y. W.,Wang, T. T.,Hua, Z. C.,Extracts from plastrum testudinis promote proliferation of rat bone-marrow-derived mesenchymal stem cells,Cell Proliferation,2007.4.4,40(2):196~212

 

二、授权发明专利

(1) 陈东风,杜少辉,李伊为,黎晖,周健洪,促骨髓间充质干细胞生长的龟板提取物及其制备方法和应用,2006.11.8,国家发明专利CN200610034579.9

(2) 黎晖,吴晶晶,杜少辉,陈东风,李伊为,周健洪,丹皮酚在制备抗内毒素血症的药物中的应用,2013.8.21,国家发明专利CN201310178504.8

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