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谈博老师简介
2022-11-04 09:31     (浏览次数:)

谈博,男,湖北省武汉人,教授,博士生导师。出身中医世家,先后毕业于北京中医药大学和广州中医药大学。哈佛大学医学院访问学者。现任广州中医药大学中医养生与预防医学系创系主任,中医养生学学科带头人;在广东省中医院肝病科出诊。社会兼职:广东省保健协会肝病专业委员会副主任委员、广东省党外知识分子联谊会理事等。主要研究方向为养生本草的治未病研究、中西医结合防治传染病和消化病的基础与临床研究。

曾跟随李国桥教授和郭兴伯教授,参与抗药性恶性疟防治新药青蒿素复方(Artequick的研制和临床前、I期、II期临床研究,“青蒿素哌喹片及灭源控疟方案的研发与国际推广”项目获得2020年度高等学校(教育部)科技进步奖一等奖和广东省科技进步奖一等奖(第四完成人)。主持国家自然科学基金面上项目2项及省市级科技项目资助3项,发表论文40余篇,其中SCI论文6篇,中国发明专利授权并转让1项。主持建设广东省一流本科专业——中医养生学,专业全国排名第二(2021-2022年软科和校友会中国大学专业排名)。主讲《中医养生学》《中医营养学》《伤寒论》《金匮要略》《中医治未病学概论》等专业主干课程。担任“十四五”国家级规划教材《中医治未病学概论》副主编、《中医养生学》编委

出身中医世家,师承于先伯父谈汉文先生,研习中医经典,并私淑张锡纯、姜春华、朱良春等先生。临床擅长治疗肝胆脾胃病,对于病毒性肝炎、脂肪肝、肝纤维化、肝硬化、肝癌等慢性肝病的中医治疗有独到之处;擅长应用丸散膏汤等调治失眠、疲乏等亚健康状态。


主要论著

1. Yi SL, Huang ZT, Liao L, Lu YL, Lin YK, Pei Y, Chen WY, Huang C, Cao HY, Tan B. The Effects of Patchouli Alcohol on Diarrhea-Predominant Irritable Bowel Syndrome are Correlated with Phenotypic Plasticity in Myenteric Neurons and the Targeted Regulation of Myosin Va. Am J Chin Med. 2022 Oct 3:1-21. doi: 10.1142/S0192415X22500811. Epub ahead of print. PMID: 36185014. IF=6.005

2.Wang R, Hong M, Huang J, Zhou N, Zhang Y, Xu S, Liu J, Yuan J, Zhang L, Huang L, Huang P, Tan B* and Cao HY*. Low-Dose Cyclophosphamide Induces Nerve Injury and Functional Overactivity in the Urinary Bladder of Rats. Front in Neurosci. 2021,15:715492. doi: 10.3389/fnins.2021.715492. IF=4.501

3.Lu YL, Huang JJ, Zhang Y, Huang ZT, Yan WM, Zhou TR, Wang ZS, Liao L, Cao HY, Tan B*. Therapeutic effects of berberine hydrochloride on stress-induced diarrhea-predominant irritable bowel syndrome rats by inhibiting neurotransmission in colonic smooth muscle. Frontiers in Pharmacology. 2021, 12:596686. IF=5.810

4.Zhang J, Zhang Y, Yang X, Wang J, Xu Y, Wang R, Tan B, Huang P, Cao H*. Diabetic bladder dysfunction in T2D KK-Ay mice and its changes in the level of relevant gene expression. Biomedicine & Pharmacotherapy. 2020 Nov;131:110706. doi: 10.1016/j.biopha.2020.110706. IF=6.529

5.Wang R, Huang ZT, Ren WK, Zhang J, Zhang Y, Tan B, Huang P, Cao HY.  Isolation and Culture of Primary Neurons and Glia from Adult Rat Urinary Bladder. Journal of Visualized Experiments. 2020;(159):10.3791/61177. 2020 May 23. IF=1.355

6.Huang Z, Liao L, Wang Z, Lu Y, Yan W, Cao H, Tan B*. An efficient approach for wholemount preparation of the myenteric plexus of rat colon. J Neurosci Methods. 2020 Nov 26;348:109012. doi: 10.1016/j.jneumeth.2020.109012. Epub ahead of print. PMID: 33249181. IF=2.214

7.王哲生,吴良琴,黄梓彤,廖璐,操红缨,谈博*.广东省727例健康人中医兼夹体质分型的横断面研究[J].中医杂志,2020,61(10):876-880.

8.Zhou TR, Huang JJ, Huang ZT, Cao HY, Tan B*. Inhibitory effect of patchouli alcohol on isolated stress-induced irritable bowel syndrome with predominant diarrhea rat colon. World J Gastroenterol. 2018, 24(6):693-705. IF=3.411

9.Huang ZT, Huang JJ, Zhou TR, Cao HY, Tan B*. Prognostic value of liver stiffness measurement for the liver-related surgical outcomes of patients under hepatic resection: A meta-analysis. PLoS One. 2018, 13(1):e0190512 .IF=2.776

10.Li XQ, Ren ZX, Li K, Huang JJ, Huang ZT, Zhou TR, Cao HY, Zhang FX, Tan B*.  Key Anti-Fibrosis Associated Long Noncoding RNAs Identified in Human Hepatic Stellate Cell via Transcriptome Sequencing Analysis. Int J Mol Sci. 2018 Feb 27;19(3). pii: E675. IF= 4.183

11.Daneshvar K, Pondick JV, Kim BM, Zhou C, York SR, Macklin JA, Abualteen A, Tan B, Sigova AA, Marcho C, Marcho C, Tremblay KD, Mager J, Choi MY, Mullen AC*. DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells. Cell Reports. 2016,17(2):353-365. IF=8.282

12.Lai H, Yan Q, Cao H, Chen P, Xu Y, Jiang W, Wu Q, Huang P, Tan B*. Effect of SQW on the bladder function of mice lacking TRPV1. BMC Complement Altern Med. 2016,16(1):465. IF=2.288

13.周天然,黄晶晶,琚欣,黄梓彤,操红缨,谈博*. 广藿香配方颗粒干预IBS-D大鼠的药效学研究[J].中药材,2018,41(1):180-183.

14.周天然,张瑶,逯晓旭,夏炎,操红缨,谈博*. 慢性束缚应激IBS-D大鼠模型的改良与评价[J].广州中医药大学学报,2018,35(01):163-168.

15.谈博,江伟雯,连大卫,许艺飞,黄萍,操红缨*. 乌药提取物对膀胱过度活动症模型膀胱上皮细胞Ca2+浓度和UPII表达的影响[J]. 中医药临床杂志,2016,06:844-848.

16.谈博,连大卫,黄涌鑫,范平龙,操红缨,黄萍*. 糖尿病膀胱功能障碍小鼠的膀胱功能及尿动力学改变[J]. 广州中医药大学学报,2016,04:573-578.

17.Huanling Lai, Bo Tan, Zhijian Liang, Qitao Yan, Qingwang Lian, Qinghe Wu, Ping Huang, and Hongying Cao*. Effect of the Chinese traditional prescription Suo Quan Wan on TRPV1 expression in the bladder of rats with bladder outlet obstruction. BMC Complement Altern Med. 2015; 15: 424.

18.Daneshvar, K., Tan, B., York, S., Molinie, B., Giallourakis, C. C., Mullen, A. C*. Long noncoding RNA in endodermal differentiation. 11th Annual MGH GI Unit Clinical and Basic Science Research Retreat, 50页,美国波士顿,2013.05.24,大会报告

19.谈博*,刘静,文思,操红缨,黄萍.人参对高脂血症小鼠肝脂质代谢紊乱的影响,中药材,2013,36(7):1149-1151

20.谈博*. 叶天士临证指南医案席姓医案评析,上海中医药杂志,2012,46(10):24-25

21.Jianping Song*, Duong Socheat, Bo Tan, Suon Seila, Ying Xu, Fengzhen Ou, Sreng Sokunthea. Randomized trials of artemisinin-piperaquine, dihydroartemisinin- piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area, Malaria journal,2011,10(8):231-238

22.Jianping Song*, Duong Socheat, Bo Tan, Prak Dara, Changsheng Deng,  Sreng Sokunthea, Suon Seila, Fengzhen Ou, Huaxiang Jian, Guoqiao Li. Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine. Malaria journal,2010,9(2): 57-67

23.Trung TN, Tan B, Van Phuc D, Song JP*. A randomized, controlled trial of artemisinin-piperaquine vs dihydroartemisinin-piperaquine phosphate in treatment of falciparum malaria. Chin J Integr Med,2009,15(3):189-192.

24.谈博,操红缨.慕课在中医养生学课程教学中的应用.中国高等医学教育,2016,(7):74-75

25.谈博,周天然.脏腑养生的说课设计.中国中医药现代远程教育, 2016, 14(14):13-15

26.谈博.失眠最伤肝[J].肝博士,2018(02):62.

27.谈博.脂肪肝合并高脂血症、糖尿病如何治疗?[J].肝博士,2018(01):53.

28.刘焕兰,谈博.天人相应理论的发展及其意义[J].广州中医药大学学报,2010,27(04):407-410.

29.刘焕兰,谈博.自我按摩养生功法源流探析[J].辽宁中医药大学学报,2010,12(07):14-15.

30.谈博. 论医药之“方”[A]. 中华中医药学会.第十次全国中医养生康复学术会议论文集[C].中华中医药学会:中华中医药学会,2012:2.

31.邓长生,宋健平,谈博,Mariata Rahamatou,Ali Silai,Abobacar Soulaiman,Moussa Mohamed,Ahamada MSA Mliva,李国桥.青蒿素哌喹片联合伯氨喹治疗科摩罗无并发症恶性疟临床疗效观察(英文)[J].广州中医药大学学报,2012,29(02):197-201.

32.谈博,宋健平,何一卿,郭卫中,郭兴伯,李国桥.口服青蒿素哌喹片在中国健康人体的耐受性[J].中国临床药理学杂志,2009,25(05):405-407.

33.宋健平,谈博,DUONG Socheat,SUOU Seila,徐颖,欧凤珍,SRENG Sokunthea,LEAP Sophorn,李国桥.青蒿素哌喹片治疗无并发症恶性疟的剂量探索试验[J].中国新药与临床杂志,2008,27(12):908-911.

34.邓长生,谈博,DUONG Socheat, SUOU Seila,徐颖,欧凤珍,SRENG Sokunthea, LEAP Sophorn, NGET Nom,宋健平.青蒿素哌喹片治疗间日疟62例临床报道[J].广州中医药大学学报,2008(03):204-206.

35.谈博,宋健平,Thou Tharith,李国桥.含与不含甲氧苄啶的两个双氢青蒿素复方治疗恶性疟的临床对照试验[J].广州中医药大学学报,2007(02):100-103.

36.谈博,操红缨.少阴病咽痛之方证考释[J].中华中医药学刊,2007(02):372-373.

37.谈博,宋健平,张奉学,刘妮,李彩君,卢如玲,郭兴伯.川芎嗪对HSC-T6细胞Smad蛋白细胞内转位的影响[J].中药新药与临床药理,2006(05):320-322.

38.宋健平,Duong Socheat,谈博,Prak Dara,李海波,Sreng Sokunthea,Suon Seila,欧凤珍,简华香,李国桥.高度疟疾流行区快速控制疟疾试验[J].广州中医药大学学报,2006(02):89-94.

39.谈博,张奉学,操红缨,郭兴伯.鸭乙型肝炎病毒感染模型及其方法学研究进展[J].热带医学杂志,2005(01):111-113+117.

40.谈博,张奉学,刘妮,郭兴伯.川芎嗪和苦参碱对HSC-T6细胞增殖的抑制作用[J].热带医学杂志,2004(06):678-681.

41.宋建平,符林春,谈博,李国桥.双氢青蒿素哌喹片治疗无并发症恶性疟的临床随机对照试验[J].中国新药与临床杂志,2004(11):783-785.

42.谈博,张奉学,刘妮,郭兴伯.丹参含药血清对肝星状细胞增生的抑制作用[J].世界华人消化杂志,2004(06):103-106.

43.张奉学,谈博,周红燕,李向阳,朱宇同,郭兴伯.乙型肝炎病毒在宿主内不受核苷类药物影响的机理探讨[J].广州中医药大学学报,2003(01):18-20+24.

44.谈博. 肝外DHBV复制治疗学意义及中药体外抗肝纤维化筛选平台的探讨[D].广州中医药大学,2002.

45.谈博,操红缨.TGF-β的信号转导的调控[J].国外医学(分子生物学分册),2002(02):76-79.

46.黄玲,谈博.中草药防治肝纤维化的研究进展[J].现代中西医结合杂志,2000(03):201-203.


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